Difference between revisions of "CometWiki"
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| + | ==CometWiki== | ||
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| + | Welcome to CometWiki. This site describes the set up and usage of `comet', an actin-based bead motility simulator. | ||
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| + | [http://en.wikipedia.org/wiki/Actin Actin] is a polymer built by cells that allows them to move. Actin-based bead motility is an ''in vitro'' model system used to study how our cells produce force and move, carried out by coating a bead with proteins that tell the cell to polymerize actin, and putting the bead a solution that mimics the material inside cells. This causes an actin network to build around the bead. Surprisingly even when the bead is spherically symmetric, rather than just buiding a symmetric shell that gets bigger and bigger, it moves off in 'comet tail' of actin. This bead motility simulated aims to help us understand how this process works. | ||
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| + | Here are some examples of the simulator output: | ||
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[http://www.dayel.com/comet/supmat/movies/FigS2_Fig1_x_proj.mov http://www.dayel.com/comet/supmat/movies/thumbnails/FigS2_Fig1_x_proj.mov.png] | [http://www.dayel.com/comet/supmat/movies/FigS2_Fig1_x_proj.mov http://www.dayel.com/comet/supmat/movies/thumbnails/FigS2_Fig1_x_proj.mov.png] | ||
[http://www.dayel.com/comet/supmat/movies/FigS3_Fig1vtkx1.mov http://www.dayel.com/comet/supmat/movies/thumbnails/FigS3_Fig1vtkx1.mov.png] | [http://www.dayel.com/comet/supmat/movies/FigS3_Fig1vtkx1.mov http://www.dayel.com/comet/supmat/movies/thumbnails/FigS3_Fig1vtkx1.mov.png] | ||
[http://www.dayel.com/comet/supmat/movies/FigS7b_Symmetric_Capsule.mov http://www.dayel.com/comet/supmat/movies/thumbnails/FigS7b_Symmetric_Capsule.mov.png] | [http://www.dayel.com/comet/supmat/movies/FigS7b_Symmetric_Capsule.mov http://www.dayel.com/comet/supmat/movies/thumbnails/FigS7b_Symmetric_Capsule.mov.png] | ||
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| + | You can find [[Examples|more examples here]]. | ||
{|cellpadding="5" | {|cellpadding="5" | ||
|width="45%" valign="top"| | |width="45%" valign="top"| | ||
| − | + | ==Installing the program== | |
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| − | ==Installing== | + | |
Detailed instructions for downloading and installing comet on OS X, Linux or Windows can be found [[Installing|here]] | Detailed instructions for downloading and installing comet on OS X, Linux or Windows can be found [[Installing|here]] | ||
Revision as of 20:49, 12 April 2009
CometWiki
Welcome to CometWiki. This site describes the set up and usage of `comet', an actin-based bead motility simulator.
Actin is a polymer built by cells that allows them to move. Actin-based bead motility is an in vitro model system used to study how our cells produce force and move, carried out by coating a bead with proteins that tell the cell to polymerize actin, and putting the bead a solution that mimics the material inside cells. This causes an actin network to build around the bead. Surprisingly even when the bead is spherically symmetric, rather than just buiding a symmetric shell that gets bigger and bigger, it moves off in 'comet tail' of actin. This bead motility simulated aims to help us understand how this process works.
Here are some examples of the simulator output:
You can find more examples here.
Installing the programDetailed instructions for downloading and installing comet on OS X, Linux or Windows can be found here Running the programSimple instructions for running the program from the command line can be found here SettingsThe program reads its settings from a file called cometparams.ini. Here is an overview of the main parameters. In Depth
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